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1

Synthesis of a transition state analogue for the hydrolysis of cocaine: Assistance to phosphonylation of a 3β-hydroxytropane by a neighbouring amide group

Eleni P Hagi-Pavli, Caroline S Simms, Elizabeth L Ostler, Keith Brocklehurst, Gerard Gallacher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 174 KB

english, 1999

2

Cysteine proteases: mode of action and role in epidermal differentiation

Keith Brocklehurst, Mike P. Philpott

Journal:

Cell and Tissue Research

Year:

2013

Language:

english

File:

PDF, 161 KB

english, 2013

3

Effect of Storage Conditions on the Microbial Ecology and Biochemical Stability of Cell Wall Components in Brewers’ Spent Grain

Robertson, James A., I’Anson, Kerry J. A., Brocklehurst, Tim F., Faulds, Craig B., Waldron, Keith W.

Journal:

Journal of Agricultural and Food Chemistry

Year:

2010

Language:

english

File:

PDF, 822 KB

english, 2010

4

THE RECOVERY OF THE SEVERELY DISABLED STROKE PATIENT

ANDREWS, KEITH, BROCKLEHURST, J. C., RICHARDS, BERNARD, LAYCOCK, P. J.

Journal:

Year:

1982

Language:

english

File:

PDF, 358 KB

english, 1982

5

A sound basis for pH-dependent kinetic studies on enzymes

Brocklehurst, Keith

Journal:

Protein Engineering Design and Selection

Year:

1994

Language:

english

File:

PDF, 1016 KB

english, 1994

6

ChemInform Abstract: Synthesis of a Transition State Analogue for the Hydrolysis of Cocaine: Assistance to Phosphonylation of a 3β-Hydroxytropane by a Neighboring Amide Group.

Eleni P. Hagi-Pavli, Caroline S. Simms, Elizabeth L. Ostler, Keith Brocklehurst, Gerard Gallacher

Journal:

Year:

1999

File:

PDF, 31 KB

1999

7

ChemInform Abstract: Polyclonal Antibody-Catalyzed Hydrolysis of a β-Lactam.

Elizabeth L. Ostler, Marina Resmini, Guillaume Boucher, Nickolas Romanov, Keith Brocklehurst, Gerard Gallacher

Journal:

Year:

2002

File:

PDF, 27 KB

2002

8

The Kinetic Basis of a General Method for the Investigation of Active Site Content of Enzymes and Catalytic Antibodies: First-Order Behaviour under Single-turnover and Cycling Conditions

CHRISTOPHER M. TOPHAM, SHERAZ GUL, MARINA RESMINI, SANJIV SONKARIA, GERRARD GALLACHER, KEITH BROCKLEHURST

Journal:

Journal of Theoretical Biology

Year:

2000

Language:

english

File:

PDF, 321 KB

english, 2000

9

Specific covalent modification of thiols: Applications in the study of enzymes and other biomolecules

Keith Brocklehurst

Journal:

International Journal of Biochemistry

Year:

1979

Language:

english

File:

PDF, 1.98 MB

english, 1979

10

Synthesis of an aminoalcohol hapten for the generation of catalytic antibodies

José Flórez-Álvarez, Keith Brocklehurst, Gerard Gallacher, Marina Resmini

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 73 KB

english, 2002

11

Papain and related proteins

BROCKLEHURST, KEITH

Journal:

Year:

1990

File:

PDF, 135 KB

1990

12

Molecular basis of the activity of the phytopathogen pectin methylesterase

Fries, Markus, Ihrig, Jessica, Brocklehurst, Keith, Shevchik, Vladimir E, Pickersgill, Richard W

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 457 KB

english, 2007

13

Biochemical and X-ray crystallographic studies on shikimate kinase: The important structural role of the P-loop lysine

Tino Krell, John Maclean, Deborah J. Boam, Alan Cooper, Marina Resmini, Keith Brocklehurst, Sharon M. Kelly, Nicholas C. Price, Adrian J. Lapthorn, John R. Coggins

Journal:

Protein Science

Year:

2001

Language:

english

File:

PDF, 575 KB

english, 2001

14

Evidence from two-protonic-state reactivity probe kinetics that chymopapain in fresh nonfruit latex ofCarica papayaconsists of multiple forms of chymopapain A. The value of catalytic site characteristics in the identification, classification, and characterization of the papaya cysteine proteinases papain, the chymopapains, and papaya proteinase Ω

Keith Brocklehurst, Raymond McKee, Erdjan Salih, Harry Smith

Journal:

The Protein Journal

Year:

1985

Language:

english

File:

PDF, 2.48 MB

english, 1985

15

Isolation and characterization of the four major cysteine-proteinase components of the latex of carica papaya L. reactivity characteristics towards 2,2′-dipyridyl disulfide of the thiol groups of papain, chymopapains A and B, and papaya peptidase A

Baldev S. Baines, Keith Brocklehurst

Journal:

The Protein Journal

Year:

1982

Language:

english

File:

PDF, 1.22 MB

english, 1982

16

Rapid purification and properties of protein kinase C from bovine adrenal medulla

Keith W. Brocklehurst, George Lee, Harvey B. Pollard

Journal:

Bioscience Reports

Year:

1986

Language:

english

File:

PDF, 659 KB

english, 1986

17

Polyclonal catalytic antibodies

Elizabeth L Ostler, Marina Resmini, Keith Brocklehurst, Gerard Gallacher

Journal:

Journal of Immunological Methods

Year:

2002

Language:

english

File:

PDF, 209 KB

english, 2002

18

Immobilization of Urease by Thiol-Disulphide Interchange with Concomitant Purification

Jan Carlsson, Rolf Axén, Keith Brocklehurst, Eric M. Crook

Journal:

Year:

1974

Language:

english

File:

PDF, 546 KB

english, 1974

19

Catalytic antibody activity elicited by active immunisation : Evidence for natural variation involving preferential stabilization of the transition state

Gerard GALLACHER, Caroline S. JACKSON, Mark SEARCEY, Rajiv GOEL, Geoffrey W. MELLOR, Carmen Z. SMITH, Keith BROCKLEHURST

Journal:

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

20

The House Dust Mite AllergenDer p1 Catalytically Inactivates α1-Antitrypsin by Specific Reactive Centre Loop Cleavage: A Mechanism That Promotes Airway Inflammation and Asthma

Noor A. Kalsheker, Susan Deam, Louise Chambers, Suneal Sreedharan, Keith Brocklehurst, David A. Lomas

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 360 KB

english, 1996

21

Enzymatically Active Papain Preferentially Induces an Allergic Response in Mice

Louise Chambers, Alan Brown, David I. Pritchard, Suneal Sreedharan, Keith Brocklehurst, Noor A. Kalsheker

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 463 KB

english, 1998

22

Kinetic and Titration Methods for Determination of Active Site Contents of Enzyme and Catalytic Antibody Preparations

Keith Brocklehurst, Marina Resmini, Christopher M. Topham

Journal:

Year:

2001

Language:

english

File:

PDF, 133 KB

english, 2001

23

Interaction of protein kinase C with chromaffin granule membranes: effects of Ca2+, phorbol esters and temperature reveal differences in the properties of the association and dissociation events

Keith W. Brocklehurst, Harvey B. Pollard

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1989

Language:

english

File:

PDF, 698 KB

english, 1989

24

The phorbol ester TPA enhances A23187- but not carbachol-and high K+-induced catecholamine secretion from cultured bovine adrenal chromaffin cells

Kyoji Morita, Keith W. Brocklehurst, Stuart M. Tomares, Harvey B. Pollard

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 334 KB

english, 1985

25

Synergistic actions of Ca2+ and the phorbol ester TPA on K+-induced catecholamine release from bovine adrenal chromaffin cells

Keith W. Brocklehurst, Harvey B. Pollard

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 503 KB

english, 1986

26

The case for assigning a value of approximately 4 to pKaI of the essential histidine-cysteine interactive systems of papain, bromelain and ficin

Michael Shipton, Marek P.J. Kierstan, J. Paul G. Malthouse, Trevor Stuchbury, Keith Brocklehurst

Journal:

Year:

1975

Language:

english

File:

PDF, 392 KB

english, 1975

27

Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells

Keith W. Brocklehurst, Harvey B. Pollard

Journal:

Year:

1985

Language:

english

File:

PDF, 356 KB

english, 1985

28

Pertussis toxin stimulates delayed-onset, Ca2+-dependent catecholamine release and the ADP-ribosylation of a 40 kDa protein in bovine adrenal chromaffin cells

Keith W. Brocklehurst, Harvey B. Pollard

Journal:

Year:

1988

Language:

english

File:

PDF, 1.12 MB

english, 1988

29

The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full-length enzymes: a possible role for the C-terminal domain

Frances Willenbrock, Gillian Murphy, Ian R. Phillips, Keith Brocklehurst

Journal:

Year:

1995

Language:

english

File:

PDF, 386 KB

english, 1995

30

Profiling brewers' spent grain for composition and microbial ecology at the site of production

James A. Robertson, Kerry J.A. I'Anson, Janneke Treimo, Craig B. Faulds, Tim F. Brocklehurst, Vincent G.H. Eijsink, Keith W. Waldron

Journal:

Lebensmittel-Wissenschaft und-Technologie / Food Science and Technology

Year:

2010

Language:

english

File:

PDF, 190 KB

english, 2010

31

A rat monoclonal antibody that catalyses the hydrolysis of a nitrophenyl-β-lactam

Elizabeth L. Ostler, Christopher J. Dean, Nicola Barber, Maurizio Valeri, Stuart James, Marina Resmini, Guillaume Boucher, Nickolas Romanov, Keith Brocklehurst, Gerard Gallacher

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 100 KB

english, 2002

32

Evidence for N → O transfer in the deacylation of an acyl-α-chymotrypsin

Keith Brocklehurst, Kenneth Williamson

Journal:

Biochemical and Biophysical Research Communications

Year:

1967

Language:

english

File:

PDF, 332 KB

english, 1967

33

Social effects of stroke

J.C. Brocklehurst, Phyllis Morris, Keith Andrews, B. Richards, P Laycock

Journal:

Social Science & Medicine. Part A: Medical Psychology & Medical Sociology

Year:

1981

Language:

english

File:

PDF, 689 KB

english, 1981

34

Evidence for the Importance of Weakly Bound Water for Matrix Metalloproteinase Activity

Willenbrock, Frances, Knight, C. Graham, Murphy, Gillian, Phillips, Ian R., Brocklehurst, Keith

Journal:

Year:

1995

Language:

english

File:

PDF, 790 KB

english, 1995

35

[New Comprehensive Biochemistry] Hydrolytic Enzymes Volume 16 || Chapter 2 Cysteine proteinases

Brocklehurst, Keith

Year:

1987

Language:

english

File:

PDF, 7.31 MB

english, 1987

36

Generation of Nucleophilic Character in the Cys25/His159 Ion Pair of Papain Involves Trp177 but Not Asp158 †

Gul, Sheraz, Hussain, Syeed, Thomas, Mark P., Resmini, Marina, Verma, Chandra S., Thomas, Emrys W., Brocklehurst, Keith

Journal:

Year:

2008

Language:

english

File:

PDF, 377 KB

english, 2008

37

Structural Insights into Substrate Specificity and the anti β-Elimination Mechanism of Pectate Lyase

Seyedarabi, Arefeh, To, Teng Teng, Ali, Salyha, Hussain, Syeed, Fries, Markus, Madsen, Robert, Clausen, Mads H., Teixteira, Susana, Brocklehurst, Keith, Pickersgill, Richard W.

Journal:

Year:

2010

Language:

english

File:

PDF, 4.46 MB

english, 2010

38

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A

Willenbrock, Frances, Crabbe, Thomas, Slocombe, Patrick M., Sutton, Chris W., Docherty, Andrew J. P., Cockett, Mark I., O'Shea, Mark, Brocklehurst, Keith, Phillips, Ian R., Murphy, Gillian

Journal:

Year:

1993

Language:

english

File:

PDF, 1.97 MB

english, 1993

39

Identification of Interactions Involved in the Generation of Nucleophilic Reactivity and of Catalytic Competence in the Catalytic Site Cys/His Ion Pair of Papain

Hussain, Syeed, Khan, Akavish, Gul, Sheraz, Resmini, Marina, Verma, Chandra S., Thomas, Emrys W., Brocklehurst, Keith

Journal:

Year:

2011

Language:

english

File:

PDF, 2.16 MB

english, 2011

40

Kinetic Analysis of the Mechanism of Interaction of Full-Length TIMP-2 and Gelatinase A: Evidence for the Existence of a Low-Affinity Intermediate †

Hutton, Mike, Willenbrock, Frances, Brocklehurst, Keith, Murphy, Gillian

Journal:

Year:

1998

Language:

english

File:

PDF, 46 KB

english, 1998

41

Polyclonal antibody-catalysed hydrolysis of a β-lactam

Ostler, Elizabeth L., Resmini, Marina, Boucher, Guillaume, Romanov, Nickolas, Brocklehurst, Keith, Gallacher, Gerard

Journal:

Chemical Communications

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

42

Towards a specific chromophoric substrate for ?-chymotrypsin

Brocklehurst, Keith, Williamson, Kenneth

Journal:

Chemical Communications (London)

Year:

1966

Language:

english

File:

PDF, 153 KB

english, 1966

43

The influence of age on the clinical presentation and outcome of stroke

Andrews, Keith, Brocklehurst, J. C., Richards, Bernard, Laycock, P. J.

Journal:

Disability & Rehabilitation

Year:

1984

Language:

english

File:

PDF, 571 KB

english, 1984

44

STROKE: DOES SIDE MATTER?

ANDREWS, KEITH, BROCKLEHURST, J.C., RICHARDS, BERNARD, LAYCOCK, P.J.

Journal:

Year:

1982

Language:

english

File:

PDF, 255 KB

english, 1982

45

THE PROGNOSTIC VALUE OF PICTURE DRAWINGS BY STROKE PATIENTS

ANDREWS, KEITH, BROCKLEHURST, J. C., RICHARDS, BERNARD, LAYCOCK, P. J.

Journal:

Year:

1980

Language:

english

File:

PDF, 432 KB

english, 1980

46

Elucidation of Substrate Specificity in the Cobalamin (Vitamin B 12 ) Biosynthetic Methyltransferases

Frank, Stefanie, Deery, Evelyne, Brindley, Amanda A., Leech, Helen K., Lawrence, Andrew, Heathcote, Peter, Schubert, Heidi L., Brocklehurst, Keith, Rigby, Steve E. J., Warren, Martin J., Pickersgill,

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 1.49 MB

english, 2007

47

[Methods in Enzymology] Affinity Techniques - Enzyme Purification: Part B Volume 34 || [66] Covalent chromatography by thiol-disulfide interchange

Brocklehurst, Keith

Year:

1974

Language:

english

File:

PDF, 715 KB

english, 1974

48

Sulfur in Proteins.by Yu M. Torchinsky; W. Wittenberg; D. Metzler

Review by: Keith Brocklehurst

Journal:

Quarterly Review of Biology

Year:

1983

Language:

english

File:

PDF, 115 KB

english, 1983

49

A necessary modification to the preparation of papain from any high-quality latex of Carica papaya and evidence for the structural integrity of the enzyme produced by traditional methods

Baines, Baldev S., Brocklehurst, Keith

Journal:

Biochemical Journal

Year:

1979

Language:

english

File:

PDF, 1.24 MB

english, 1979

50

Covalent chromatography. Preparation of fully active papain from dried papaya latex

Brocklehurst, Keith, Carlsson, Jan, Kierstan, Marek P. J., Crook, Eric M.

Journal:

Biochemical Journal

Year:

1973

Language:

english

File:

PDF, 1.79 MB

english, 1973